Research Practice

The Bosmere Medical Practice is a Sessional Research Practice and as member of the Clinical Research Network Wessex we usually participate in up to fifteen new research studies every year.

Ayshea Hind is our Lead Nurse Practitioner and Research Co-ordinator and Dr König is our GP Research Lead.

The purpose of conducting medical research is to obtain robust scientific evidence to establish whether or not new treatments do indeed have the effects that we think they might, as until this research has been conducted, we do not know whether one particular treatment will be more or less effective than another.

Study Title Study Design Study Objective
Access study

(Bristol University)

Questionnaire survey to evaluate patient access to electronic medical test result in general practice across England. The results of this work will allow policy makers and the NHS, including the many practices currently not offering patients electronic access to their test results, to consider how best to implement these services in the future to improve patient care.
Active Brains Study

(Southampton University)

REducing and preventing COgnitive impairment iN older age groups (The RECON Programme)

 

Feasibility trial

To evaluate a new website called ‘Active Brains’ which aims to help older adults to look after their brain and body health, to prevent dementia. The website will help older adults to make simple changes such as getting more active, playing brain training games and finding ways to eat more healthily.
ATTACK

(Southampton University)

Aspirin To Target Arterial Events In Chronic Kidney Disease (CKD)

 

Pragmatic multicentre open-label randomised controlled trial

Does low-dose aspirin (75mg) reduce the chance of a first heart attack or stroke in patients with chronic kidney disease?
CLASP

(Southampton University)

Cancer: Life Affirming Survivorship support in Primary care Programme

 

“Renewed Online” Feasibility Study.

This study aims to evaluate “Renewed Online” – an online intervention offering lifestyle and wellbeing support for colon, prostate and breast cancer survivors.
DECIDE (PRIM 5039)

(Liverpool University)

Pragmatic Randomised 104 Week Multicentre Trial to Evaluate the Comparative Effectiveness of dapagliflozin and Standard of Care in Type 2 Diabetes. The study will help doctors to decide whether dapagliflozin is a suitable long- term treatment for patients with type 2 diabetes who have not been able to achieve good diabetic control on other drugs, when used in real life practice.

 

Study Title Study Design Study Objective
Eczema Care Online (ECO)

(Southampton University)

Two multi-centre randomised controlled trials with internal pilots and nested health economic evaluations and mixed-methods process evaluation studies. One trial is for young people with eczema (trial-YP) and one for parents/carers of children with eczema (trial-PC) To determine the clinical and cost- effectiveness of two online interventions for eczema: one for young people with eczema (intervention-YP) and one for parents/carers of children with eczema (intervention-PC).

 

Awaiting start date

Empathica Development

(Southampton University)

Empathy and Expectation Management for Patients in Primary Care: Developing a New Digital Intervention for Practitioners Development of online training package for practitioners (GPs, physiotherapists, and nurses) to enhance their consultation skills to show more empathy and encourage patients with osteoarthritis to have positive yet realistic expectations.

The ultimately aim is to improve the long- term effectiveness of all drug and non- drug therapies for osteoarthritis pain, and to reduce patients’ pain and improve quality of life.

MERIT

(Oxford University)

D-MannosE to prevent Recurrent urine InfecTions

 

A randomized, double-blinded placebo-controlled trial

D-Mannose may offer a valuable alternative to antibiotic prophylaxis in women who experience recurrent UTIs, and in turn it may contribute to better antimicrobial stewardship in primary care.

Patients take 2g of D-Mannose or placebo each day for 6 months.

UTI to be treated as normal, but send study team specimen pre- and post UTI.

PROMDEP

(Southampton University)

Patient-Reported Outcome Measures for monitoring primary care patients with DEPression: PROMDEP randomised controlled trial. Active use of the Patient Health Questionnaire (PHQ-9) score to guide treatment and improve outcome in patients with new episodes of depression.
REDUCE

(Southampton University)

REviewing long term anti- DEpressant Use by Careful monitoring in Everyday practice

 

WS4:Pilot Feasibility Randomised Controlled Trial

The REDUCE study aims to identify safe, effective, and cost-effective ways of helping patients taking long-term antidepressants taper off and stop treatment, when appropriate.
SupportBack2

(Southampton University)

Supporting self-management of low back pain (LBP) with an internet intervention in primary care: A randomised controlled trial of clinical and cost-effectiveness To determine the clinical effectiveness of the SupportBack intervention on LBP- related physical disability delivered with and without telephone physiotherapist support in addition to usual care, compared to usual care alone.

 

Study Title Study Design Study Objective
Spironolactone for Adult Female Acne (SAFA) (Southampton University) Spironolactone for Adult Female Acne: A pragmatic multicentre double-blind randomised superiority trial to investigate the clinical and cost-effectiveness of spironolactone for moderate or severe persistent acne in women To determine the clinical effectiveness of spironolactone compared with

placebo, in addition to standard care, in the treatment of moderate or severe persistent facial acne in adult women.

ATLANTIS

(Leeds University)

Amitriptyline at Low-dose and Titrated for Irritable Bowel Syndrome as Second-line Treatment (The ATLANTIS study): A Double-blind Placebo-controlled Trial To determine the clinical and cost- effectiveness of low-dose amitriptyline as a second-line treatment for IBS in primary care.

 

Expression of interest to participate submitted

SNIFSII: Saline Nasal Irrigation For acute Sinusitis II (Southampton University) This study aims to randomise more than 100 people with acute sinus infections presenting in primary care to either a) immediate antibiotics (current usual treatment in primary care) or b) advice to perform nasal irrigation for up to 3 weeks with a ‘back-up’ or delayed antibiotic prescription (a prescription that can be used if the sinusitis does not settle). This study will provide preliminary evidence as to whether or not nasal irrigation is an acceptable and effective measure that may help reduce the use of antibiotics in acute sinusitis – evidence that is required for the application for a future full trial.

 

 

Expression of interest to participate submitted

Spectrum 10k

(Cambridge University)

The Spectrum 10K study wishes to recruit 10,000 autistic individuals and where possible their families to deeply phenotype these individuals and their families. Large Scale Autism Study to explore the biology and genetics of autistic traits and to investigate how autistic traits and environmental factors are related to autism.

 

Expression of interest to participate submitted

TriOptimize (RESP43001)

(Chiesi Limited)

A prospective non-interventional trial on COPD patients’ health- related quality of life under a fixed LAMA/LABA/ICS triple therapy and characterization of determinants of treatment adherence To assess changes in health-related quality of life in COPD patients for whom the treating clinician has decided to prescribe Trimbow®.

 

Expression of interest to participate submitted