Research
At the Bosmere Medical Practice 2024-2025
The Bosmere Medical Practice is a Sessional (Level 3) Research Practice, and as member of the Clinical Research Network Wessex we usually participate in up to ten new research studies every year.
Dr König is our GP Research Lead, and our Practice Nurse Debbie Foulis is our Research Co-ordinator.
The purpose of conducting medical research is to obtain robust scientific evidence to establish whether new treatments do indeed have the effect that we think they might, as until this research has been conducted, we do not actually know if one treatment will be more (or less) effective than another.
Currently recruiting studies:
| Study Title | Study Design | Study Objective |
DaRe2THINK trial (Birmingham University)
| The use of healthcare Data for pragmatic Research (primary 2 secondary care) to prevent stroke, cognitive decline and premature death in a broader community of patients with atrial fibrillation.
Randomised controlled trial
| Can stroke, cognitive decline and premature death in patients with atrial fibrillation be prevented by commencing direct oral anticoagulants (DOACs) at a younger age/ lower treatment threshold? |
Discover Me (Omnigen Biodata)
https://www.omnigenbiodata.co.uk/
Patient self-enrolment P
| Discover Me is a nationwide research study looking at how health and genetic information can allow us to better understand disease.
If interested in participating please enrol here:
https://uk.discovermestudy.com/ods/J82010
| As part of Discover Me you can learn more about your own health, thereby supporting you and your doctor in making better decisions about your health and future care.
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Headway®
(Family Mental Wealth, South London and Maudsley NHS Foundation Trust, Sussex University)
| Clinical Focus Group to evaluate the new Headway® Insight Tool App, facilitated by Health Innovation Wessex. | Tackling Childhood Obesity through digital self-help tools that address underlying psychological drivers for emotional eating.
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Reduce Carbon study (Portsmouth Hospitals University) | RandomisED controlled trial to understand whether prescribing Choice for inhalErs is influenced by knowledge of the CARBON footprint
| Does knowledge of the CARBON footprint of inhalers influence the prescribing choice of clinicians? |
REFLEX study (Southampton University)
| FibroScan®(Reflex testing) for metabolic associated fatty liver disease (MAFLD) in patients living with type 2 diabetes compared to usual care.
Randomised controlled trial
| 70% of patients living with T2DM have a fatty liver (a risk factor for serious liver damage), so to identify the 70%, the study team will test everyone enrolled for liver disease.
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TIGER study (Bristol University)
https://tiger.blogs.bristol.ac.uk/ 
Patient self-enrolment P
| Trial of food allergy (IgE) tests for Eczema Relief
Randomised controlled trial
Many parents wonder whether their child’s eczema might be caused by a food allergy.
Parents of children aged three months to two years can express an interest by emailing:
tiger-study@bristol.ac.uk.
| Does food allergy testguided dietary advice improve disease control in children aged < 2 with eczema? |
Recent studies:
| Study Title | Study Design | Study Objective |
(Bristol University)
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Questionnaire survey to evaluate patient access to electronic medical test result in general practice across England. |
The results of this work will allow policy makers and the NHS, including the many practices currently not offering patients electronic access to their test results, to consider how best to implement these services in the future to improve patient care.
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Active Brains study (Southampton University) | REducing and preventing COgnitive impairment iN older age groups (The RECON Programme)
Feasibility trial | To evaluate a new website called ‘Active Brains’ which aims to help older adults to look after their brain and body health, to prevent dementia. The website will help older adults to make simple changes such as getting more active, playing brain training games and finding ways to eat more healthily.
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ASYMPTOMATIC trial (Alder Hey Children’s NHS Foundation Trust)
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Assessing Symptom-driven versus Maintenance Preventer Therapy for the Outpatient Management of AsThma In Children
Randomised controlled trial
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In children with mild asthma, is taking the preventer inhaler only when symptomatic as effective as taking it every day? |
| ATLANTIS trial (Leeds University) | Amitriptyline atLow-dose and Titrated for Irritable Bowel Syndrome as Second-line Treatment.
Double-blind placebo-controlled trial. | To determine the clinical and costeffectiveness of low-dose amitriptyline as a second-line treatment for IBS in primary care.
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ATTACK trial (Southampton University) |
Aspirin To Target Arterial Events In Chronic Kidney Disease (CKD)
Pragmatic multicentre open-label randomised controlled trial
| Does low-dose aspirin (75mg) reduce the chance of a first heart attack or stroke in patients with chronic kidney disease?
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Breathe4T study (Southampton University)
| Breathing Retraining for Asthma -randomised controlled trialof home exercises for asthmatic Teenagers
| Mobile-friendly website to teach breathing exercises to adolescents who suffer asthma attacks.
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DZ-D100 Dermocamera and DZ-S50 Dermoscope (CASIO Computer Co., Tokyo)
| Observational industry study | Trial of the DZ-D100 Dermocamera and the DZ-S50 Dermoscope in UK General Practice, and provision of feedback and marketing advice to CASIO Computer Co., Japan.
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Eczema Care Online study (Southampton University) | Two multi-centre randomised controlled trials with internal pilots and nested health economic evaluations and mixed-methods process evaluation studies. One trial is for young people with eczema and one for parents of children with eczema)
| To determine the clinical and costeffectiveness of two online interventions for eczema: one for young people with eczema (intervention-YP) and one for parents/carers of children with eczema (intervention-PC).
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Immune Defence study (Southampton University)
| 4-arm randomised trial | To investigate the effectiveness and costeffectiveness of commonly available nasal sprays and a brief physical activity and stress management intervention in preventing and reducing the incidence, severity, and duration of RTIs among patient at risk of serious infection in the COVID pandemic
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MERIT trial (Oxford University) | D-MannosE to prevent Recurrent urine InfecTions A randomized, double-blinded placebo-controlled trial | D-Mannose may offer a valuable alternative to antibiotic prophylaxis in women who experience recurrent UTIs, and in turn it may contribute to better antimicrobial stewardship in primary care. Patients take 2g of D-Mannose or placebo each day for 6 months. UTI to be treated as normal, but send study team specimen pre- and post UTI.
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PEGMED study (Southampton University)
| Parental Experience of Giving their children liquid MEDications: real-world acceptability and adherence of liquid formulation antibiotics in children
| The objective is to assess the acceptability of and adherence to liquid oral antibiotics with a view to improving antibiotic guidelines across primary and secondary care.
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PRINCIPLE trial (Oxford University)
| Anyone experiencing COVID-19 symptoms, which started within the last 14 days, may be eligible to join the PRINCIPLE trial if they | This trial has tested existing medication to reduce the symptoms of COVID-19 in the community and prevent the need for hospital admission. |
are aged over 65, or over 50 with an underlying health condition.
| It showed that Hydroxychloroquine, Azithromycin and Doxycycline are ineffective in the treatment of Covid-19, and inhaled budesonide was the first widely available drug found to shorten recovery times in COVID-19 patients aged over 50 who are treated at home and in other community settings.
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PROMDEP study (Southampton University) | Patient-Reported Outcome Measures for monitoring primary care patients with DEPression: PROMDEP randomised controlled trial. | Active use of the Patient Health Questionnaire (PHQ-9) score to guide treatment and improve outcome in patients with new episodes of depression.
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| REDUCE (workstream 5) (Southampton University) | REviewing long term antiDepressant Use by Careful monitoring in Everyday practice
Randomised Controlled Trial
| The REDUCE study aims to identify safe, effective, and cost-effective ways of helping patients taking long-term antidepressants to taper off and stop treatment (when appropriate). |
SAFER trial (Cambridge University) | Screening for Atrial Fibrillation with ECG to Reduce stroke
Individuals at high risk of stroke self-screen for AF for 3 weeks via a single lead ECG in their own home.
Randomised controlled trial
| Atrial fibrillation is a common irregular heartbeat which can increase someone’s risk of stroke 5-fold. Treatment with medication can reduce this risk.
The researchers want to find out if screening high-risk patients for atrial fibrillation is feasible, will prevent strokes and is good value for money for the NHS.
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Female Acne (SAFA) (Southampton University) | Spironolactone for Adult Female Acne: A pragmatic multicentre double-blind randomised superiority trial to investigate the clinical and cost-effectiveness of spironolactone for moderate or severe persistent acne in women | To determine the clinical effectiveness of spironolactone compared with placebo, in addition to standard care, in the treatment of moderate or severe persistent facial acne in adult women. |
SuMMiT-D trial (Oxford University) | Support through Mobile Messaging and digital health Technology for Diabetes
Randomised controlled trial
| To compare with usual care the effectiveness and cost effectiveness of brief messaging to help type 2 diabetics on medication reduce their risk of diabetic complications.
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SupportBack2 trial (Southampton University) | Supporting self-management of low back pain (LBP) with an internet intervention in primary care: A randomised controlled trial of clinical and costeffectiveness | To determine the clinical effectiveness of the SupportBack intervention on LBPrelated physical disability delivered with and without telephone physiotherapist support in addition to usual care, compared to usual care alone.
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T2T Gout trial (Keele University)
| Treat to Target in gout study.
Individually tailored uric acid lowering treatment in the intervention arm.
Randomised controlled trial
| What is the clinical and cost-effectiveness of using a goal-directed allopurinol-based treatto-target protocol in people with high uric acid levels and recurrent gout flares?
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